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The Duke Blue Devils were one of the most dominant college basketball teams in the country during the regular season and were rewarded with the No. 1 seed in the East Region of the 2025 NCAA Tournament bracket. Duke continued its dominance during the first two rounds of March Madness 2025, beating No. 16 Mount St. Mary’s, 93-49, in the first round, and No. 9 Baylor, 89-66, in the second round. Head coach Jon Scheyer and the Blue Devils will take on No. 4 Arizona on Thursday in the Sweet 16. Does Duke, led by National Player of the Year candidate Cooper Flagg, have what it takes to advance to the program’s 18th Final Four and win its sixth national title? Should the Blue Devils be on upset alert against Arizona in the 2025 NCAA bracket Sweet 16? Before locking in any March Madness predictions, be sure to see the 2025 NCAA Tournament bracket picks from the proven computer model at SportsLine.
SportsLine’s proven projection model has simulated every game in the tournament 10,000 times. It has absolutely crushed its March Madness picks recently, beating over 91% of all CBS Sports brackets in four of the past six tournaments. The model nailed 13 of the 16 teams in the Sweet 16, and all four of its Final Four teams are still in the field. It knows how to spot an upset as well. The same model has produced brackets that have nailed 25 first-round upsets by double-digit seeds since its inception in 2016.
There’s no reason to rely on luck when there’s proven technology to help you dominate your 2025 March Madness picks. Now, with the remainder of the 2025 NCAA bracket revealed, the model is simulating the matchups and its results are in. You can only see it over at SportsLine.
Top 2025 NCAA Tournament Sweet 16 picks
One of the Sweet 16 picks from the model: No. 2 seed Tennessee, despite losing to Kentucky twice this season, beats the Wildcats on Friday. Tennessee was dominant in its first two games of the NCAA Tournament, beating Wofford 77-62 in the first round, and then defeating UCLA 67-58 in the second round. The Vols have advanced to the Sweet 16 in three straight NCAA Tournaments, and are coming off an Elite 8 appearance in 2024.
Guards Chaz Lanier, Zakai Zeigler, and Jordan Gainey give the Vols a noticeable advantage in the backcourt. Zeigler and Gainey were both key players in Tennessee’s Elite 8 run last season, while Lanier was a Transfer Portal addition during the offseason. Tennessee is one of the best defensive teams in college basketball, and Rick Barnes’ veteran-heavy roster is built for success in March. You can see the model’s 2025 NCAA bracket picks here.
How to make 2025 NCAA bracket predictions
SportsLine’s model also says the Final Four will feature something that hasn’t happened in almost 20 years. With the model’s track record of calling bracket-busting upsets, you’ll want to see which teams it’s picking this year before locking in any 2025 NCAA bracket picks.
So what’s the optimal NCAA Tournament 2025 bracket, and what historic Final Four does the model predict? Visit SportsLine now to see which teams you can back with confidence, all from the model that has called 25 first-round upsets by double-digit seeds and nailed 13 Sweet 16 teams this year.
