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The UConn Huskies are two-time defending national champions, but their road to a third consecutive title will be more challenging than ever after the 2025 NCAA Tournament bracket was revealed on Sunday. UConn suffered 10 losses this season and was seeded No. 8 in the West Region of the 2025 March Madness bracket, where they will take on No. 9 seed Oklahoma. Looming large for the winner of that game will likely be No. 1 seed Florida, who won the SEC Tournament title over Tennessee on Sunday.
Meanwhile, Duke is the No. 1 seed in the East Region, but will face questions after superstar freshman Cooper Flagg suffered an ankle injury in the ACC Tournament. Successfully identifying 2025 March Madness Cinderellas and 2025 March Madness upset picks poised to make a deeper than expected run is one of the best ways to make sure your 2025 NCAA bracket picks stand out. Before making any 2025 March Madness bracket predictions, be sure to check out the 2025 NCAA Tournament bracket picks from the proven computer model at SportsLine.
Their proven projection model has simulated every game in the tournament 10,000 times. It has absolutely crushed its March Madness picks recently, beating over 91 percent of all CBS Sports brackets in four of the past six tournaments. It was all over UConn’s championship run a year ago and nailed 13 teams in the Sweet 16. It also nailed Alabama’s Cinderella run to the Final Four as a 4-seed.
It knows how to spot an upset as well. The same model has produced brackets that have nailed 24 first-round upsets by double-digit seeds since its inception in 2016. There’s simply no reason to rely on luck when there’s proven technology to help you dominate your 2025 March Madness bracket picks.
Now, with the 2025 NCAA bracket revealed, the model is simulating the matchups and its results are in. You can only see it over at SportsLine.
Three 2025 March Madness bracket games to watch
One of the most intriguing 2025 March Madness matchups to watch: No. 5 Michigan vs. No. 12 UC San Diego in the South region. This is a classic 5 vs. 12 matchup between a powerhouse in collegiate athletics and an upstart mid-major program. UC San Diego is making its first NCAA Tournament appearance after winning the Big West regular-season and tournament titles on its way to a 30-win season. Meanwhile, Michigan won the Big Ten Tournament on Sunday over Wisconsin and is led by a pair of seven-footers in Vladislav Goldin and Danny Wolf. This is Dusty May’s first season leading the Wolverines, but he did lead FAU to the Final Four in 2023.
Another 2025 NCAA Tournament matchup to keep an eye on is No. 8 Louisville vs. No. 9 Creighton in the South Region. Ryan Kalkbrenner is one of the most familiar names participating in March Madness 2025, with the Creighton center winning Big East Defensive Player of the Year honors four times and playing a pivotal role for the Bluejays in the NCAA Tournament the last four years. However, Louisville went 18-2 in the ACC this season and was the runner-up to Duke for both the regular-season and tournament titles. Pat Kelsey’s first year at the helm has already yielded 27 wins for the Cardinals, but this is Louisville’s first March Madness appearance since 2019.
Another 2025 March Madness game to watch out for: No. 4 seed Texas A&M will battle No. 13 seed Yale in the South Region. This is familiar territory for the Bulldogs, who upset an SEC team as a No. 13 seed a season ago. Yale beat Auburn last season for its second NCAA Tournament win under head coach James Jones. Meanwhile, Texas A&M ended a late-season skid by upsetting No. 1 overall seed Alabama late in the regular season and also had high-profile wins at Ole Miss and Missouri (both No. 6 seeds) during SEC play. The Aggies also beat Purdue and Creighton on a neutral floor during non-conference play and they’ve proven that they can get hot at any time with microwave scorers like Wade Taylor IV and Zhuric Phelps in their backcourt. You can see the model’s 2025 NCAA bracket picks here.
How to make 2025 NCAA bracket predictions
Who wins every tournament-defining matchup? And which teams will make surprising runs through the 2025 NCAA Tournament bracket? With the model’s track record of calling bracket-busting upsets, you’ll want to see which stunners it’s calling this year before locking in any 2025 NCAA bracket picks.
So what’s the optimal NCAA Tournament 2025 bracket? And which NCAA Tournament Cinderella teams will shock college basketball? Visit SportsLine now to see which double-digit seeds you can back with confidence, all from the model that called UConn’s national title and nailed 13 Sweet 16 teams in 2024.
