MLB Opening Day 2025: Schedule, matchups, previews and more – ESPN

Mar 18, 2025, 04:30 PM ET

The major league regular season kicked off in Japan this week — meaning MLB Opening Week is just around the corner.

On March 27, 28 of 30 MLB teams will play in 14 Opening Day games. ESPN will broadcast two of them: the first of the day, Brewers-Yankees, in the late afternoon and a primetime matchup between the reigning champion Dodgers and the Tigers. Meanwhile, the Rays and Rockies will play their first game the following day, March 28.

Thirty of the best pitchers across the majors will take the mound, including 22 All-Stars, four pitchers who will be debuting for new clubs and one who will become the fastest top overall pick to take the mound in a season opener.

What are the most important things to know from the offseason going into the 162-game marathon that is the 2025 season? What are the most exciting matchups on March 27? What are some storylines to watch?

We have you covered on everything you need to be prepared for Opening Day, from season previews and analysis to the schedule.

Opening Day schedule

Thursday, March 27

(All times ET)

3:05 p.m. on ESPN: Milwaukee Brewers at New York Yankees

The pitching matchup: Freddy Peralta vs. Carlos Rodón

3:07 p.m.: Baltimore Orioles at Toronto Blue Jays

The pitching matchup: Zach Eflin vs. Jose Berrios

4:05 p.m.: Boston Red Sox at Texas Rangers

The pitching matchup: Garrett Crochet vs. Nathan Eovaldi

4:05 p.m.: Philadelphia Phillies at Washington Nationals

The pitching matchup: Zack Wheeler vs. MacKenzie Gore

4:10 p.m.: Cleveland Guardians at Kansas City Royals

The pitching matchup: TBD vs. Cole Ragans

4:10 p.m.: New York Mets at Houston Astros

The pitching matchup: Clay Holmes vs. Framber Valdez

4:10 p.m.: San Francisco Giants at Cincinnati Reds

The pitching matchup: Logan Webb vs. Hunter Greene

4:10 p.m.: Atlanta Braves at San Diego Padres

The pitching matchup: Chris Sale vs. Michael King

4:10 p.m.: Los Angeles Angels at Chicago White Sox

The pitching matchup: Yusei Kikuchi vs. Sean Burke

4:10 p.m.: Pittsburgh Pirates at Miami Marlins

The pitching matchup: Paul Skenes vs. Sandy Alcantara

4:15 p.m.: Minnesota Twins at St. Louis Cardinals

The pitching matchup: Pablo Lopez vs. Sonny Gray

7:10 p.m. on ESPN: Detroit Tigers at Los Angeles Dodgers

The pitching matchup: Tarik Skubal vs. TBD

10:10 p.m.: Chicago Cubs at Arizona Diamondbacks

The pitching matchup: TBD vs. TBD

10:10 p.m.: Athletics at Seattle Mariners

The pitching matchup: Luis Severino vs. Logan Gilbert

Friday, March 28

4:10 p.m.: Colorado Rockies at Tampa Bay Rays

The pitching matchup: Kyle Freeland vs. Shane McClanahan

2025 season guides

Fantasy baseball cheat sheet

Jeff Passan’s 2025 season preview: Predictions, inside intel and breakout stars for all 30 teams

Which young players will rock 2025? Ranking the top prospects in MLB’s Spring Breakout

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