Padres vs. Guardians Prediction, Odds, Picks - April 1

Data Skrive

Manny Machado and the San Diego Padres will play Steven Kwan and the Cleveland Guardians on Tuesday at PETCO Park, at 9:40 p.m. ET. The Padres are -162 moneyline favorites for this matchup against the Guardians (+137). San Diego is a 1.5-run favorite (at +134 odds). The total is 7.5 runs for the contest (with -111 odds on the over and -109 odds to go under).

Take a look at everything you need to know from a betting perspective on the Padres-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Yuli Gurriel drove in a run to give the San Diego Padres a 1-0 lead in the bottom of the 7th inning over the Atlanta Braves.

Padres vs. Guardians Game Information & Odds

When: Tuesday, April 1, 2025 at 9:40 p.m. ET
Where: PETCO Park in San Diego, California
How to watch on TV: SDPA and CLEG

Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Padres -162 +137 7.5 -111 -109 -1.5 +134 -159

Padres vs. Guardians Prediction

Score Prediction: Guardians 5, Padres 3
Total Prediction: Over 7.5 runs
Win Probabilities: Padres 67%, Guardians 33%

Padres vs. Guardians Betting Insights

The Padres won 64 of the 106 games they were listed as the moneyline favorite last season (60.4%).
San Diego had a record of 22-11 when it played as a moneyline favorite with odds of -162 or shorter last year (66.7%).
Based on this matchup’s moneyline, the Padres’ implied win probability is 61.8%.
The Guardians were underdogs in 65 games last season and won 29 (44.6%) of those contests.

Padres Player Insights

Machado slugged 29 home runs and collected 105 RBI last season while batting .275.
Jackson Merrill collected 162 hits, posted an OBP of .326, and a .500 SLG.
Luis Arraez finished last season with a .314 batting average while adding four home runs and 46 RBI.
Jake Cronenworth collected 139 hits, posted an OBP of .324 and a .390 SLG.

Guardians Player Insights

Jose Ramirez had 39 home runs and 118 runs batted in last season.
Kwan had a .292 batting average with 140 hits.
Carlos Santana hit .238 last season with 26 doubles, 23 home runs and 65 walks.
Lane Thomas had 26 doubles, three triples, 15 home runs and 44 walks while batting .237.

Yuli Gurriel drove in a run to give the San Diego Padres a 1-0 lead in the bottom of the 7th inning over the Atlanta Braves.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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San Diego Padres

Cleveland Guardians

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