Purdue vs McNeese picks, predictions, odds: Who wins March Madness NCAA Tournament game?

No. 12 seed McNeese and No. 4 seed Purdue play Saturday, March 22 in a March Madness NCAA Tournament second-round game at Amica Mutual Pavilion in Providence, Rhode Island.

The Midwest Region game is scheduled for 9:10 a.m. MST and can be seen on CBS (stream with FUBO).

Who will win the March Madness game and advance to the Sweet 16 in the NCAA bracket?

Check out these NCAA Tournament second-round picks and predictions for the men’s college basketball matchup.

Purdue is a 5.5-point favorite over McNeese in the game in March Madness odds provided by BetMGM Sportsbook. The Boilermakers are -250 on the moneyline. The Cowboys are +200. The over/under for the game is set at 143.5 points.

FOLLOW THE MADNESS: NCAA men’s tournament bracket, scores, schedules, teams and more.

Watch McNeese vs Purdue on FUBO (free trial)

The Arizona Republic: Purdue 73, McNeese 66

Jeremy Cluff writes: “The Cowboys only shot 43.5% from the field and 21.1% from 3 in their win over Clemson, but held the Tigers to 36.8% shooting from the field. It’s going to be much harder to contain Trey Kaufman-Renn and Braden Smith in the second round. We don’t think they will be able to contain them.”

Dimers: Purdue 78, McNeese 72

It writes: “After extensive simulations, our model gives McNeese State a win probability of 29%, while Purdue has a win probability of 71%.”

March Madness schedule, TV channels: How to watch, stream NCAA Tournament second round

Lafayette Journal & Courier: Purdue 77, McNeese 68

Sam King writes: “Did Purdue dodge a bullet with Clemson being upset? Or are the Boilermakers at risk of losing to another double-digit seed? Any team that wins an NCAA Tournament game is capable of winning another and Purdue will (again) be a popular upset pick. Purdue didn’t shoot well from 3 against High Point. I anticipate that to change on Saturday.”

March Madness TV announcers schedule: Who is calling NCAA Tournament second-round games?

FOX Sports: Purdue 74, McNeese 70

It writes: “Purdue has put together an 18-15-0 ATS record so far this year. McNeese has won 16 games against the spread this year, while failing to cover 16 times. Purdue has been favored by 5.5 points or more 18 times this season, and covered the spread in 12 of those contests. McNeese has been an underdog by 5.5 points or more three times this season, and covered the spread each time.”

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March Madness odds: Point spreads, moneylines, over/unders for NCAA Tournament second round

ESPN: Purdue has a 76.8% chance to beat McNeese

The site gives the Cowboys a 23.2% shot at defeating the Boilermakers in Saturday’s second-round March Madness NCAA Tournament game.

More: Printable March Madness bracket for making 2025 NCAA Tournament picks, predictions

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Reach Jeremy Cluff at [email protected]. Follow him on X, formerly Twitter @Jeremy_Cluff.

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